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Expert opinion Our analysis indicated that, under certain stress-related conditions, these precursors are cleaved to form immunologically active peptides that rapidly leave the nucleus and intracellular spaces, to send distress signals to the immune system, thereby acting as stress sensors

Using the arginine deiminase analog ADI-PEG-20 in hepatocellular carcinoma and glioblastoma has demonstrated antitumor activity in vitro and in xenograft models and demonstrated safety and efficacy in a phase I clinical trial

Further studies have shown that in rats, the administration of 1.0 mg/kg AS-IV for up to four weeks during gestation can induce fur formation, eye opening and neurodevelopmental lag in newborn rats but does not affect the cognitive function of newborn rats (38)

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